000			03389cam a22004094a 4500
008			090714s2007 paua b 001 0 eng
010			_a2006-028271
020			_a9780781782104
020			_a0781782104
035			_avtls009627512
039		9	_a201512091036 _bAUTHORITY _c201512091023 _dAUTHORITY _y200907140857 _zmschk03
040			_aDNLM/DLC _cDLC _dDLC _dSTUSCHK1
042			_apcc
082	0	0	_a610.72 _222
245	0	0	_aDesigning clinical research / _cStephen B. Hulley ... [et al.].
250			_a3rd ed.
260			_aPhiladelphia, PA _bLippincott Williams & Wilkins _c2007.
300			_axv, 367 p. _bill. _c26 cm.
504			_aIncludes bibliographical references and index.
505	0		_aGetting started: the anatomy and physiology of clinical research / Stephen B. Hulley, Thomas B. Newman, and Steven R. Cummings -- Conceiving the research question / Steven R. Cummings, Warren S. Browner, and Stephen B. Hulley -- Choosing the study subjects: specification, sampling, and recruitment / Stephen B. Hulley, Thomas B. Newman, and Steven R. Cummings -- Planning the measurements: precision and accuracy / Stephen B. Hulley and Steven R. Cummings -- Getting ready to estimate sample size: hypotheses and underlying principles / Warren S. Browner, Thomas B. Newman, and Stephen B. Hulley -- Estimating sample size and power: applications and examples / Warren S. Browner, Thomas B. Newman, and Stephen B. Hulley -- Designing an observational study: cohort studies / Steven R. Cummings, Thomas B. Newman, and Stephen B. Hulley -- Designing an observational study: cross-sectional and case-control studies / Thomas B. Newman ... [et al.] -- Enhancing causal inference in observational studies / Thomas B. Newman, Warren S. Browner, and Stephen B. Hulley --
505	0		_aDesigning a randomized blinded trial / Steven R. Cummings, Deborah Grady, and Stephen B. Hulley -- Alternative trial designs and implementation issues / Deborah Grady, Steven R. Cummings, and Stephen B. Hulley -- Designing studies of medical tests / Thomas B. Newman, Warren S. Browner, and Steven R. Cummings -- Research using existing databases: secondary data analysis, ancillary studies, and systematic reviews / Deborah Grady and Norman Hearst -- Addressing ethical issues / Bernard Lo -- Designing questionnaires and interviews / Steven R. Cummings and Stephen B. Hulley -- Data management / Michael A. Kohn -- Implementing the study: pretesting, quality control, and protocol revisions / Stephen B. Hulley and Steven R. Cummings.
650		0	_aClinical trials.
650		0	_aMedicine _xResearch _xMethodology.
650		0	_aepidemiológia
650	1	2	_aepidemiológia
650	2	2	_aResearch Design.
700	1		_aHulley, Stephen B.
856	4	1	_3Table of contents only _uhttp://www.loc.gov/catdir/toc/ecip0619/2006028271.html
856	4	2	_3Publisher description _uhttp://www.loc.gov/catdir/enhancements/fy0712/2006028271-d.html
906			_a7 _bcbc _corignew _d1 _eecip _f20 _gy-gencatlg
910			_aSCHK95
919			_a978-0-7817-8210-4
925	0		_aacquire _b2 shelf copy _xpolicy default
955			_djc02 2006-08-28 _ejc02 2006-08-28 to Dewey _flf27 2007-02-16 _glf27 2007-02-16 to BCCD
985			_aNLMCIP _d2006-08-25
999			_c36 _d36